Who selects investigators?

• A. Ethics Committee.
• B. Sponsor.
• C. Data Safety Monitoring Board.
• D. Regulatory Authority.

Answer: (B)

In trials, the sponsor is responsible for appointing the investigators who will conduct the study. The sponsor needs to ensure that each investigator has the appropriate qualifications, training, experience, and facilities to carry out the protocol and protect participant safety. This appointment is usually formalized through contracts or agreements and includes verifying that the site can meet GCP requirements, provide necessary resources, and maintain proper oversight.

Ethics committees (IRBs) review and approve the protocol and protect participant rights and safety, but they do not select or appoint investigators. Data Safety Monitoring Boards focus on monitoring safety and data integrity during the trial, not on site selection. Regulatory authorities review and approve the protocol and overall trial conduct, but their role is oversight rather than appointing investigators.