Who supervises the research team?

• A. Principal Investigator (PI)
• B. Clinical Research Coordinator (CRC)
• C. Sponsor's monitor
• D. IRB member

Answer: (A)

The principal investigator is the person responsible for the overall conduct of the study at the site and for the safety and rights of participants. They ensure protocol adherence, regulatory compliance, informed consent, adverse event reporting, and data integrity, and they supervise the research team to ensure those standards are met. The clinical research coordinator assists with day-to-day tasks under the PI's direction but does not supervise the entire team. The sponsor's monitor provides independent oversight and checks on compliance and data quality during visits, not ongoing supervision of site staff. An IRB member reviews and approves the protocol from an ethics standpoint, but they do not manage trial operations.